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capsaicin n.【化學】辣椒素。

These neurotoxins were found to activate the same receptor on sensory nerves that produces the burning sensation animals get from capsaicin , the “ hot “ ingredient in chilies 研究發現,這些毒素與辣椒素(使辣椒呈現紅色的成分)使動物產生灼痛感一樣,都是刺激感覺神經上相同的感受器。

These neurotoxins were found to activate the same receptor on sensory nerves that produces the burning sensation animals get from capsaicin , the “ hot “ ingredient in chilies 研究發現,這些毒素與辣椒素(使辣椒呈現紅色的成分)使動物產生灼痛感一樣,都是刺激感覺神經上相同的感受器。

capsian

The results showed that : ? apsaicin could significantly increase the frequency of miniature excitatory postsynaptic currents ( mepscs ) , in another word , capsaicin could enhance the excitatory neurotransmitter release from primary afferent terminals . this is coincidence with the results of our previous studies 第四軍醫大學碩士學位論文結果表明: coys能顯著增加所記錄的微小興奮性突觸后電流( miniatureexcitatorypostsympticcurrents , inepscs )的頻率,即增強了初級傳入終末釋放興奮性神經遞質,這與我們以往的研究結果一致。

? he pretreatment of ne together with yohimbine , an a , adrenergic receptor antagonist , had no effect on the facilitatory action of capsaicin on neurotransmitter release from primary afferent terminals . this result suggests that the a2 adrenergic receptor on primary afferent terminals might be involved in ne depression on capsaicin - induced neurotransmitter release 將飛型腎上腺素受體阻滯劑育亨賓( yohimbine )與ne同時預灌流后, caps對初級傳入終末遞質釋放的易化作用不受影響,提示初級傳入纖維終末上的a 。

Secondly , we examined the actions of nociceptin on excitatory and inhibitory synaptic transmission to sg neurons . we finally observed the effect of anandamide on membrane current of sg neurons and on excitatory synaptic transmission to sg neurons . the comparison of anandamide and capsaicin actions was also analyzed De對脊髓背角sg神經元膜電流的影響作用以及其對脊髓背角興奮性突觸傳遞的作用并將其作用與capsaicin進行了比較研究。

The selective action of capsaicin on primary afferent fibers that transmit nociceptive information simulates nociceptive stimulation in vivo , therefore , the ne depression of primary afferent terminal neurotransmitter release might be significant on nociceptive modulation at spinal level Caps選擇性地作用于傳遞傷害性信息的初級傳入纖維,模擬了在體傷害性刺激,因此, ne對初級傳人終末遞質釋放的抑制,在脊髓水平的傷害性信息調控過程中可能具有重要意義。

In 1997 cloned capsaicin receptor brought spark to studying nielsen hypothesis , and dr . d . j . julius of california university , who cloned the receptor , donates of vanilloid receptor 1 ( vr1 ) cdna to us so as to our studying work begin 1997年辣椒素受體的克隆給nielsen假設的研究帶來生機,而美國加州大學舊金山分院細胞與分子藥理學研究所d . j . julius博士(克隆辣椒素受體發明人)贈送的vr1 (型辣椒素受體) - cdna使我們的研究工作得以開展。

This ion channel , present in the membrane of many nociceptors , responds not only to capsaicin , the pungent ingredient in chili peppers , but also to distressful heat and to protons ( the hydrogen ions that make substances acidic ) ; protons are unusually abundant in inflamed tissue 該受體是一種離子通道,出現在許多痛覺受器的細胞膜上,不只對辣椒的辛辣成份起反應,也對傷人的熱及質子(造成酸性的氫離子,在發炎組織中特別多)起反應。

Results indicate that the capsaicin was evidently active in inhibiting both the bacteria and the fungi and showed strong inhibitory effects on these pathogens in a concentration dependent manner , exhibiting a stronger inhibition to the test bacteria than to the test fungi 結果表明,辣椒堿具有廣譜的抗菌范圍和較強的拮抗病原菌的活性,且抗菌活性有明顯的量效關系,其中辣椒堿對供試細菌的拮抗作用遠大于對供試真菌的作用。

Topical creams containing capsaicin are being prescribed to relieve the itching , prickling and stinging sensations that can accompany postoperative wound healing or nerve impairments stemming from hiv infection , bouts of herpes and diabetes 對于手術后傷口復原或是神經受損(因感染人類免疫不全病毒、皰疹發作以及糖尿病所造成)而出現搔?及刺痛感的病人,醫生會開立含有辣椒素的外用藥膏,以消除疼痛。

Similarly , hobbling only the capsaicin receptors might not mitigate all proton - mediated pain , because under certain circumstances , protons activate a separate population of detectors , called asics ( acid - sensing ion channels ) , on nociceptors 同理,只把辣椒素受體給限制住,或許也不會消除所有由質子所引起的痛覺;因為在某些情況下,質子可活化痛覺受器上、另一批稱為酸感性離子通道( asic )的偵測器。

Activating of the capsaicin receptor is a important tache in nielsen hypothesis , it might be used for testifying . but at that time capsaicin receptor was not cloned , so the condition for studying the hypothesis was immature 在nielsen假設中有一個很重要的環節,就是甲醛作為配子體對辣椒素受體的激活,但在dr . nielsen提出假設時辣椒素受體還沒有克隆出來,對此假設的研究自然不夠方便。

So the capsaicin receptor was confirmed to express in oocytes . after we stimulated the cells with a series concentration ( 10 - 4m and 10 - 3m ) of formaldehyde ( n = 3 ) , the formaldehyde was able to activate the capsaicin receptor 然后我們用一系列濃度的甲醛刺激模型細胞,發現甲醛確實可以激活辣椒素受體,并且在甲醛濃度與辣椒素受體的反應大小之間還可能存在量效關系。

Capsaicin acts on a type of nerve cell associated with pain ; a study recently published in nature ( described here ) found that combining capsaicin with a derivative of the numbing agent lidocaine blocked pain in rats 辣椒素對與疼痛相關的一種神經細胞有作用,一項最近發表在《自然》 (好象是)的研究發現辣椒素和一種麻醉劑利多卡因的衍生物聯合使用阻斷了貓的痛覺。

As apoptosis is normally thought to be immunologically quiescent , the authors suggest that capsaicin - induced apoptosis is immunologically actie ? this is in accordance with recent reports for other apoptotic agents , such as - irradiation 而一般認為凋亡是一種免疫靜默,本文作者暗示辣椒素誘導的凋亡一種免疫激活這與最近報道其他致凋亡劑作用一致,例如-射線。

? e did not influence the spontaneous mepsc in sg . however , after pretreatment with ne , the facilitatory effect of capsaicin on neurotransmitter release from primary afferent terminals was significantly depressed Ne對sg內自發的ilepscs無影響,但在ne預灌流后, caps增強初級傳入終末神經遞質釋放的程度顯著降低。

The potency of capsaicin as an immuno - actie ligand together with its cytotoxic effects and the induction of a specific immune response could make it an attractie candidate for cancer immunotherapy 辣椒素具有免疫激活配體的潛能、細胞毒作用及特異免疫反應的誘導,以上三個作用使其成為癌癥免疫治療有吸引力的候選者。

Besides , capsaicin was added to ketchup to make an antiseptic experiment , and the obtained results show that capsaicin could effectively inhibit some microorganisms and prolong the shelf life of the ketchup 將辣椒堿添加到番茄醬中進行防腐試驗的結果表明,辣椒堿可有效的抑制微生物的生長,從而延長番茄醬的貯藏期。

The anti - pathogenic activities of capsaicin , which was extracted from the chosen hot pepper , against three pathogenic bacteria and seven pathogenic fungi were evaluated 摘要從紅辣椒中提取的辣椒堿對金黃色葡萄球菌、大腸桿菌、枯草芽孢桿菌這3種常見的病原細菌及黑曲霉、啤酒酵母等7種病原真菌進行拮抗試驗。